Liquisolid Compact Tablet of Candesartan Cilexetil with Enhanced Solubility using Neusilin US2, Aerosil 200 and Transcutol HP
نویسندگان
چکیده
منابع مشابه
Solubility Enhancement of Carvedilol Using Liquisolid Compact Technique
A novel liquisolid compact technique was used for soulbility enahncement of poorly water soluble drug carvedilol (CAR). CAR was dissolved in water miscible non volatile solvent and then adsorbed on a solid carrier which was later compacted with other excipient into a tablet. The tablets were characterized with respect to hardness, friability, disintegration and in-vitro dissolution profile. Eff...
متن کاملEvaluation of Sorptive Properties of Various Carriers and Coating Materials for Liquisolid Systems.
The basic principle of liquisolid systems formulation lies in the conversion of the drug in a liquid state into an apparently dry, free-flowing and readily compressible powder by its blending (or spraying) with specific carriers and coating materials. The selection of the most suitable carrier and coating material depends especially on their values of flowable liquid retention potential (Φ), wh...
متن کاملFormulation and Evaluation of Immediate Release Tablet of Carvedilol using Liquisolid Compacts Technique for Solubility Enhancement
Aim: The aim of this study was to formulate and evaluate liquisolid compact system of carvedilol to give increased dissolution rate of drug by utilizing PEG400 as the non-volatile liquid vehicle. Materials and Methods: The liquisolid tablets formulated with PEG400 at different concentrations. The suitable analytical method based on UV-visible spectrophotometer was developed for carvedilol. Resu...
متن کاملBioequivalence study of two formulations of candesartan cilexetil tablet in healthy subjects under fasting conditions
INTRODUCTION The present study was conducted to compare the bioavailability of two candesartan cilexetil 16 mg tablet formulations (test and reference formulations). MATERIALS AND METHODS This study was a randomized, single- blind, two-period, cross-over study which included 24 healthy adult male and female subjects under fasting conditions. The pharmacokinetic parameters were determined base...
متن کاملPreparation of Candesartan Cilexetil Nanoparticles by Precipitation
The ADME of a drug involves its transport across cell membranes. This process is essential and influenced by the characteristics of the drug, especially its molecular size and shape, solubility at the site of its absorption, relative lipid solubility, etc. Over the last ten years, the number of poorly soluble drugs has steadily increased. One of the progressive ways for increasing bioavaibility...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Indian Journal of Pharmaceutical Education and Research
سال: 2019
ISSN: 0019-5464
DOI: 10.5530/ijper.53.3.78